The global COVID-19 pandemic has highlighted the need for novel antiviral strategies, and the extreme urgency of situation suggests that repurposing existing therapeutics (particularly those with an established safety profile and a scalable manufacturing processes) is the most efficient development strategy. Bold Therapeutics’ lead asset, BOLD-100, is a novel antiviral strategy for COVID-19 that is optimally placed for rapid clinical deployment.
Bold Therapeutics’ BOLD-100 is a first-in-class anti-resistance small molecule therapeutic currently in clinical development for some of the most difficult-to-treat cancer indications. BOLD-100 is currently in clinical trials for the treatment of gastrointestinal cancers.
BOLD-100 targets GRP78, an important protein that is utilized by viruses, including coronaviruses, to enter host cells and replicate. The literature supports that BOLD-100 will have potent antiviral activity, including against COVID-19.
Bold Therapeutics is currently working with a leading group of COVID-19 experts and collaborators to develop BOLD-100. We are currently seeking development partners and/or institutional investors interested in rapidly moving this unique solution into clinical trials.
Extensive worldwide patent protection including composition of matter, method of use (including antiviral), and manufacturing process through mid to late 2030s.
Including preclinical antiviral results, COVID-19 scientific rationale/plan, and phase I oncology results.
COVID-19 is a life-threatening condition with limited approved therapies.
BOLD-100 is a unique antiviral approach for COVID-19.
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Ibrahim IM, Abdelmalek DH, Elshahat ME, Elfiky AA. COVID-19 spike-host cell receptor GRP78 binding site prediction [published online ahead of print, 2020 Mar 10]. J Infect. 2020;S0163-4453(20)30107-9. doi:10.1016/j.jinf.2020.02.026
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